Tobias Deuse, MD and Sonja Schrepfer, MD, PhD Lead Research Team Unearthing New Clues to Stem Cell Transplant Rejection
UCSF News - - August 20, 2019
Mutations in Mitochondrial DNA Induced by Cell Reprogramming May Trigger Immune Response
In 2006, scientists discovered a way to "reprogram" mature cells – adult skin cells, for example – into stem cells that could, in principle, give rise to any tissue or organ in the body. Many assumed it was only a matter of time until this groundbreaking technique found its way into the clinic and ushered in a regenerative medicine revolution.
Because the same patient would be both the donor and the recipient of cells derived from these so-called induced pluripotent stem cells (iPSCs), these cells [...]