Lucy Kornblith, MD, Co-Investigator on $2M DOD/CDMRP 2-year Grant in Collaboration with UCSF Dept. of Lab Medicine and OHSU Trauma Surgery
UCSF surgeon-scientist Lucy Zumwinkle Kornblith, MD is a co-investigator on a newly awarded $2M Department of Defense Congressionally Directed Medical Research Program in collaboration with the UCSF Department of Laboratory Medicine, and OHSU Division of Trauma, Critical Care, and Acute Care Surgery, for the study of “Freeze Dried Platelet Extracellular Vesicles as a Hemostatic Adjunct to Resuscitation for Prolonged Field Care.”
The DOD/CDMRP funded study is a multicenter, multi-investigator grant with primary investigators Dr. Shibani Pati (Department of Lab Medicine, UCSF) and Dr. Martin Schreiber (Chief of Division of Trauma, Critical Care, and Acute Care Surgery, OHSU).
This two year grant will explore how therapeutic product derived from platelets called platelet derived extracellular vesicles (PEVs) and lyophilized platelet derived extracellular vesicles (LPEVs) can act to stop bleeding trauma patients from bleeding to death or dying from organ failure.
Dr. Kornblith noted the signficance of the research:
The short shelf life of liquid stored platelets (5 days) makes it almost impossible to provide platelets on the battlefield or to the medics and doctors responsible for immediate treatment of bleeding combat casualties on the battlefield.
LPEVs are predicted to be stable for as long as two years, are easy to use, and could be made available at all levels of care. This product may benefit service members who are acutely injured and in the long run these therapies may protect their organ function, which can often be compromised years later and could have benefited from early protective interventions such as LPEVs.
The information gained from these studies can ultimately assist in developing treatment protocols designed to save lives in both military and civilian settings and decrease the long term effects of injury.
About Dr. Lucy Kornblith
Surgeon-scientist Lucy Zumwinkle Kornblith, MD is an Assistant Professor in the UCSF Department of Surgery, Division of General Surgery, Trauma and Surgical Critical Care at Zuckerberg San Francisco General (ZSFG) and co-Chair of the Muriel Steele Society.